Abstract
In a comparative study on the fluid and electrolyte excretion of 90 patients with chronic renal failure (serum creatinine greater than or equal to 3.0 mg/dl) 100 and 200 mg torasemide (1-isopropyl-3- ([4-(3-methyl-phenylamino)pyridine]-3-sulfonyl)urea) vs. 100 and 200 mg furosemide were administered intravenously. A long-acting salidiuretic effect was demonstrated for torasemide. Torasemide can thus be categorized as a high-ceiling, long-acting diuretic. Tolerance of both diuretics was comparable.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Adult
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Aged
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Blood Pressure / drug effects
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Chlorides / blood
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Clinical Trials as Topic
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Creatinine / blood
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Diuretics / administration & dosage
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Diuretics / therapeutic use*
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Double-Blind Method
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Female
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Furosemide / administration & dosage
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Furosemide / therapeutic use*
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Heart Rate / drug effects
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Humans
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Kidney Failure, Chronic / drug therapy*
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Male
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Middle Aged
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Potassium / blood
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Random Allocation
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Sodium / blood
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Sulfonamides / administration & dosage
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Sulfonamides / therapeutic use*
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Torsemide
Substances
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Chlorides
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Diuretics
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Sulfonamides
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Furosemide
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Sodium
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Creatinine
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Potassium
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Torsemide