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Antimicrob Agents Chemother. 1988 Mar;32(3):319-23.

Antibacterial activities of fluorovinyl- and chlorovinylglycine and several derived dipeptides.

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1
Merck, Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065.

Abstract

The in vitro antibacterial activities of several halovinylglycine compounds and their L-norvalyl peptide derivatives are presented. The most potent of them, L-norvalyl-L-chlorovinylglycine, displayed good activity against gram-positive organisms, including methicillin-resistant Staphylococcus species. Chlorovinylglycine is an efficient inhibitor of alanine racemase, but the antibacterial activity of L-norvalyl-L-chlorovinylglycine may involve other physiological targets as well.

PMID:
3284459
PMCID:
PMC172167
[Indexed for MEDLINE]
Free PMC Article
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