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Anticancer Res. 1988 Jan-Feb;8(1):1-7.

Oncogene expression in adenocarcinomas of the colon and in colon tumor-derived cell lines.

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1
Department of Genetics, University of Texas, M.D. Anderson Hospital and Tumor Institute, Houston 77030.

Abstract

Six colon cancer cell lines, 13 colon tumors and ten normal colon tissues were analyzed for RNA expression using probes for c-myc, c-k-ras, c-myb, and c-fos and for the p53, TGF-alpha, and EGF receptor genes. No aberrant transcripts were detected. Levels of expression in tumors ranged from two-fold below that of normal tissue when the v-fos probe was used to 10 fold above the normal level when the c-myc probe was used. Enhanced c-myc expression was also observed in the cell lines. Southern and DNA dot blot analyses revealed c-myc amplification in three of the six cell lines.

PMID:
3282475
[Indexed for MEDLINE]
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