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Am J Clin Pathol. 1988 Apr;89(4):521-5.

Impaired parasite growth and increased susceptibility to phagocytosis of Plasmodium falciparum infected alpha-thalassemia or hemoglobin Constant Spring red blood cells.

Author information

1
Department of Biochemistry, Faculty of Science, Ramathibodi Hospital, Bangkok, Thailand.

Abstract

In vitro multiplication of Plasmodium falciparum in hemoglobin H or hemoglobin Constant Spring red blood cells (from homozygotes or double heterozygotes) was significantly reduced as compared with that in normal erythrocytes. The parasitized genetically abnormal red blood cells showed furthermore a high propensity for being phagocytosed by peripheral blood monocytes. Both impaired parasite growth and increased susceptibility to phagocytosis may be related to mechanisms for protection of the variants from P. falciparum infection.

PMID:
3281435
DOI:
10.1093/ajcp/89.4.521
[Indexed for MEDLINE]

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