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Biophys Chem. 1977 Jun;7(1):33-9.

Association kinetics with coupled diffusion. An extension to coiled-chain macromolecules applied to the lac repressor-operator system.


The association of a molecule onto a specified binding site on a large chain-like macromolecule is described in the "sliding" model, where the molecule is allowed to move along the chain in a one-dimensional diffusion which is coupled to the three-dimensional diffusion in solution. The present work extends a previous one by treating the chains more generally as coiled instead of straight. The model is applied to the lac repressor-operator association. A general expression for the rate of unspecific attachment to a chain-like macromolecule is also derived.

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