New convolutional neural network model for screening and diagnosis of mammograms

PLoS One. 2020 Aug 13;15(8):e0237674. doi: 10.1371/journal.pone.0237674. eCollection 2020.

Abstract

Breast cancer is the most common cancer in women and poses a great threat to women's life and health. Mammography is an effective method for the diagnosis of breast cancer, but the results are largely limited by the clinical experience of radiologists. Therefore, the main purpose of this study is to perform two-stage classification (Normal/Abnormal and Benign/Malignancy) of two- view mammograms through convolutional neural network. In this study, we constructed a multi-view feature fusion network model for classification of mammograms from two views, and we proposed a multi-scale attention DenseNet as the backbone network for feature extraction. The model consists of two independent branches, which are used to extract the features of two mammograms from different views. Our work mainly focuses on the construction of multi-scale convolution module and attention module. The final experimental results show that the model has achieved good performance in both classification tasks. We used the DDSM database to evaluate the proposed method. The accuracy, sensitivity and AUC values of normal and abnormal mammograms classification were 94.92%, 96.52% and 94.72%, respectively. And the accuracy, sensitivity and AUC values of benign and malignant mammograms classification were 95.24%, 96.11% and 95.03%, respectively.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast / diagnostic imaging
  • Breast Neoplasms / diagnosis*
  • Databases, Factual
  • Datasets as Topic
  • Deep Learning*
  • Early Detection of Cancer / methods*
  • Female
  • Humans
  • Mammography / methods*
  • Mass Screening / methods*
  • Radiographic Image Interpretation, Computer-Assisted / methods*

Grants and funding

This work was supported by The General Object of National Natural Science Foundation (61772358), International Cooperation Project of Shanxi Province (NO. 201603D421014), International Cooperation Project of Shanxi Province (NO. 201603D421012), and the Graduate Education Innovation Project of Shanxi Province (2020SY528).