Correlation between vitamin D level and coronary artery calcification

Hamidreza Sajjadieh; Amirreza Sajjadieh; Zahra Kasaei Koopaei; Shahram Oveisgharan

doi:10.4103/jrms.JRMS_1080_18

Correlation between vitamin D level and coronary artery calcification

J Res Med Sci. 2020 May 22:25:51. doi: 10.4103/jrms.JRMS_1080_18. eCollection 2020.

Authors

Hamidreza Sajjadieh¹, Amirreza Sajjadieh¹, Zahra Kasaei Koopaei², Shahram Oveisgharan³

Affiliations

¹ Department of Internal Medicine, Isfahan University of Medical Science, Isfahan, Iran.
² Department of Pathology, Isfahan University of Medical Science, Isfahan, Iran.
³ Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

Abstract

Background: Considering the role of Vitamin D in cardiovascular disease (CVD) and the relationship between coronary artery calcification (CAC) and CVD, we aimed to investigate the association between the serum level of Vitamin D and CAC.

Materials and methods: This was a cross-sectional study on 67 consecutive patients who were referred for performing computed tomography angiography. We used Spearman correlation to evaluate the relationship between Vitamin D and CAC and then linear regressions to control for demographics and vascular risk factors.

Results: There was no association between CAC and Vitamin D levels (Spearman coefficient = -0.03, P = 0.805). After controlling for age, sex, hypertension, hyperlipidemia, diabetes mellitus, and smoking, there was still no association between Vitamin D and CAC score (estimate = 0.001, S. E. = 0.020, P = 0.942).

Conclusion: We did not find the association between the serum level of Vitamin D and coronary artery calcification.

Keywords: Atherosclerosis; Vitamin D; computed tomography angiography; coronary artery diseases; vascular calcification.