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Neuron. 1988 Apr;1(2):127-32.

Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human.

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  • 1Department of Neurology (Neuroscience), Harvard Medical School, Boston, Massachusetts 02115.


The growth-associated protein (GAP-43) is considered a crucial component of an effective regenerative response in the nervous system. Its phosphorylation by protein kinase C correlates with long-term potentiation. Sequence analysis of human cDNAs coding for this protein shows that the human GAP-43 gene is highly homologous to the rat gene; this homology extends into the 3'-untranslated region. However, the human protein contains a 10 amino acid insert. Somatic cell hybrids demonstrate localization of the GAP-43 gene to human chromosome 3 and to mouse chromosome 16.

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