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Klin Wochenschr. 1977 May 15;55(10):475-9.

[Studies on the question of a possible autoregulation of insulin secretion (author's transl)].

[Article in German]

Abstract

In eight normal weight healthy volunteers it was proved by C-peptide assay whether high concentrations of insulin in serum would suppress the secretion of insulin in an autoregulative manner. Insulin combined with glucose, therefore was given intravenously as a single bolus injection as well as an infusion over a period of two hours. Moreover it was proved whether high levels of insulin would suppress the reactivity of the B-cell to sulphonylurea administration. It was demonstrated that the secretion of the B-cell is regulated only by the concentration of the blood sugar, but not by the level of serum insulin. Likewise the stimulation of the B-cell by sulphonyl-urea administration is not suppressed by high concentrations of insulin.

PMID:
327147
DOI:
10.1007/bf01489005
[Indexed for MEDLINE]

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