Plasmonics meets super-resolution microscopy in biology

Micron. 2020 Oct:137:102916. doi: 10.1016/j.micron.2020.102916. Epub 2020 Jul 15.

Abstract

Super-resolution microscopy can reveal the subtle biological processes hidden behind the optical diffraction barrier. Plasmonics is a key nanophotonic that combines electronics and photonics through the interaction of light with the metallic nanostructure. In this review, we survey the recent progresses on plasmonic-assisted super-resolution microscopy. The strong electromagnetic field enhancement trapped near metallic nanostructures offers a unique opportunity to manipulate the illumination scheme for overcoming the diffraction limit. Plasmonic nanoprobes, exploited as surface-enhanced Raman scattering (SERS) and plasmon-enhanced fluorescence nanoparticles, are a major category of contrast agent in super-resolution microscopy. The outstanding challenges, future developments, and potential biological applications are also discussed.

Keywords: Plasmon-enhanced fluorescence; Plasmonics; Super-resolution; Surface enhanced raman scattering.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biology / methods*
  • Electronics / methods*
  • Fluorescence
  • Metal Nanoparticles / chemistry
  • Microscopy / classification
  • Microscopy / methods*
  • Nanostructures / chemistry
  • Optics and Photonics / methods*