Agranulocytosis

Neutrophils are the most abundant white blood cell in blood and play a critical role in providing innate immunity against various offending agents. Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving severe and dangerous neutropenia. Agranulocytosis is a condition in which the absolute neutrophil count (ANC) is less than 100 neutrophils per microlitre of blood. People with this condition are at a very high risk of severe infection. Broadly, it can be due to hereditary disease due to genetic mutation or acquired disease. Agranulocytosis can have various presentations, including fever, chills, sore throat, etc. It can be a life-threatening condition that requires prompt diagnosis and treatment.