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Neurosci Res. 1988 Oct;6(1):72-5.

Intracellular picrotoxin blocks pentobarbital-gated Cl- conductance.

Author information

1
Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Abstract

Using the 'inside-out' configuration of frog sensory neurons, we studied the effect of intracellular picrotoxin on the pentobarbital-gated single channel response of Cl- -current (iCl). The pentobarbital-induced iCl showed no voltage-dependency and the single channel conductance (gamma Cl) was 16 +/- 3.1 pS (n = 6). Picrotoxin caused the pentobarbital-gated Cl- channels to react in a flickering pattern and then finally caused them to cease their opening altogether. This inhibitory action of picrotoxin was reversible.

PMID:
3264396
DOI:
10.1016/0168-0102(88)90007-7
[Indexed for MEDLINE]

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