Format

Send to

Choose Destination
Nature. 1988 Oct 27;335(6193):796-801.

The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens.

Author information

1
Howard Hughes Medical Institute, Denver, Colorado.

Abstract

T cells with V beta 3+ alpha beta receptors are deleted by self-tolerance in mice with particular major histocompatibility complex/self-antigen combinations. This also occurs for other V beta elements. Polymorphism in the major histocompatibility complex and/or the self-antigens that cause massive deletion of T cells using particular V beta elements may be maintained by the need to balance the advantage of a diverse T-cell repertoire against the potential involvement of those elements in autoimmune disease.

PMID:
3263572
DOI:
10.1038/335796a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center