Format

Send to

Choose Destination
Nature. 1988 Aug 25;334(6184):676-82.

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

Author information

1
Clinical Immunology Research Centre, University of Sydney, New South Wales, Australia.

Abstract

Immunological tolerance has been demonstrated in double-transgenic mice expressing the genes for a neo-self antigen, hen egg lysozyme, and a high affinity anti-lysozyme antibody. The majority of anti-lysozyme B-cells did not undergo clonal deletion, but were no longer able to secrete anti-lysozyme antibody and displayed markedly reduced levels of surface IgM while continuing to express high levels of surface IgD. These findings indicate that self tolerance may result from mechanisms other than clonal deletion, and are consistent with the hypothesis that IgD may have a unique role in B-cell tolerance.

PMID:
3261841
DOI:
10.1038/334676a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center