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Mutat Res. 1988 Mar-Apr;207(3-4):107-9.

Loss of penicillinase plasmids of Staphylococcus aureus after treatment with L-ascorbic acid.

Author information

1
Departamento de Microbiología, Lusara AE, Mexico D.F.

Abstract

When 2 clinical strains of plasmid-mediated penicillin-resistant Staphylococcus aureus were treated with 1 mM sodium ascorbate for 6 h, 12-35% colony-forming units (CFU) irreversibly lost their ability to produce beta-lactamase. Agarose gel electrophoresis showed the disappearance of the plasmid bands from the lysates of colonies in which susceptibility to penicillin was induced by ascorbate treatment. Since ascorbic acid is a compound that is completely non-toxic, the possibility of its therapeutic use in the treatment of multiresistant bacterial diseases is proposed.

PMID:
3258647
[Indexed for MEDLINE]

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