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J Neurosci. 1988 Feb;8(2):709-14.

Interleukin-1 is an astroglial growth factor in the developing brain.

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  • 1Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.


The immunomodulator interleukin-1 (IL-1) is found to be an astroglial growth factor during development of the mammalian brain. In vitro studies indicate that ameboid microglia, a class of brain mononuclear phagocytes, are the likely source of IL-1. Examination of different brain regions during development shows IL-1 production only after the appearance of ameboid microglia. These observations suggest that brain mononuclear phagocytes secrete growth factors that regulate normal growth and development of the CNS.

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