Polysaccharide-Based Nanoparticles for Two-Step Responsive Release of Antitumor Drug

Hong-Guang Fu; Yong Chen; Qilin Yu; Yu Liu

doi:10.1021/acsmedchemlett.0c00040

Polysaccharide-Based Nanoparticles for Two-Step Responsive Release of Antitumor Drug

ACS Med Chem Lett. 2020 May 18;11(6):1191-1195. doi: 10.1021/acsmedchemlett.0c00040. eCollection 2020 Jun 11.

Authors

Hong-Guang Fu¹, Yong Chen¹, Qilin Yu¹, Yu Liu¹

Affiliation

¹ State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.

Abstract

A novel two-step in situ method for targeted antitumor drug release by supramolecular assembly (Fc-CPT@HACD) was constructed using camptothecin prodrug (Fc-CPT) and β-cyclodextrin (β-CD)-modified hyaluronic acid (HACD). Benefiting from the overexpressed H₂O₂ and glutathione (GSH) in tumor cells, Fc-CPT@HACD can be disassembled by oxidation of ferrocene (Fc) to Fc⁺, leading to an efficient release of the anticancer drug camptothecin (CPT) to induce tumor cell apoptosis without affecting normal cells. The in vivo experiment results also demonstrated that Fc-CPT@HACD possessed higher anticancer efficiency than free CPT, accompanied by negligible side effects.