Toxin Glycan Binding: Lectin Keys Unlocking Host and Tissue Specificity

Erik Petersen; Samuel I Miller

doi:10.1016/j.chom.2020.05.019

Toxin Glycan Binding: Lectin Keys Unlocking Host and Tissue Specificity

Cell Host Microbe. 2020 Jun 10;27(6):851-853. doi: 10.1016/j.chom.2020.05.019.

Authors

Erik Petersen¹, Samuel I Miller²

Affiliations

¹ Department of Health Sciences, East Tennessee State University, Johnson City, TN 37614, USA.
² Department of Microbiology, University of Washington, Seattle, WA 98195, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: millersi@uw.edu.

PMID: 32526179
DOI: 10.1016/j.chom.2020.05.019

Abstract

In this issue of Cell Host and Microbe, Lee et al. define the glycan binding specificity of a variant of typhoid toxin produced by a non-typhoidal Salmonellae serotype. The authors elegantly demonstrate that tissue and host specificity of the toxin are related to specific glycan binding characteristics of the toxin.

Publication types

Comment

MeSH terms

Humans
Lectins
Organ Specificity
Polysaccharides
Salmonella
Typhoid Fever*
Virulence

Substances

Lectins
Polysaccharides