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Chemotherapy. 1988;34 Suppl 1:30-3.

Comparative study of ceftriaxone and cefoperazone in the treatment of acute cholecystitis.

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Gastrointestinal Surgery Unit, Cantonal Hospital, University of Geneva, Switzerland.


Forty patients with acute cholecystitis were divided into two randomized groups on the basis of the emergency antimicrobial therapy received, and were treated for a period of 5 days. The first group was given ceftriaxone (Rocephin), the second cefoperazone (Cefobis). This concomitant antimicrobial treatment of acute cholecystitis proved to be effective in 85% of the patients; 15% underwent 'à chaud' surgery on the 6th day because of a lack of response to the treatment. Ceftriaxone and cefoperazone proved to be equally effective. Use of ceftriaxone, however, was simpler (one injection a day) and the cost of treatment substantially lower.

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