Format

Send to

Choose Destination
Antimicrob Agents Chemother. 1988 Dec;32(12):1854-8.

Production and isolation of reuterin, a growth inhibitor produced by Lactobacillus reuteri.

Author information

1
Department of Microbiology, North Carolina State University, Raleigh 27695.

Abstract

Lactobacillus reuteri is a prominent member of the Lactobacillus population in the gastrointestinal ecosystem of humans, poultry, swine, and other animals. Reuterin is a newly discovered, broad-spectrum antimicrobial substance produced by this species during fermentation of glycerol. In this report, we describe procedures for (i) producing reuterin in sufficient amounts to isolate from a fermentation mixture and (ii) isolating this substance by high-performance liquid chromatography. By using uniformly labeled [14C]glycerol, reuterin was identified as a product of glycerol fermentation associated with the production of beta-hydroxypropionic acid and trimethylene glycol.

PMID:
3245697
PMCID:
PMC176032
DOI:
10.1128/aac.32.12.1854
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center