Acute experiments in cats have revealed that every successive contraction of the jejunum or ileum increases spontaneous afferent and sympathetic efferent discharges in small branches of mesenteric nerves. The increased sympathetic efferent activity either limits or suppresses the contraction of the intestine portion. The above interrelationships among neural links of the regulation is also maintained by the closing of peripheral reflexes in the splanchnic plexus' nodes. These and other relevant data suggested a mechanism of the self-regulation of the intestine motility.