A number of significant advances (omics and bioengineering) now enable seamless stratification of patients according to their individual genotypes. This allows for more precise diagnoses coupled with patient phenotypes and improved treatment planning and predictable outcomes. Collectively, these advances are designated as "personalized dental medicine." To become an essential part of personalized dental medicine, this term will have a robust impact on dental implant practice. This narrative review elucidates the importance of utilizing advanced bioengineering techniques and biotechnologies in the realm of dental implants, aiming to understand gene expression profiles controlling endosseous wound healing and promoting bone formation. Thus, the first objective of the review was to present the state of the art of conceptualizing osseointegration as a phenomenon. The second objective was to pave the way for personalized dental implant therapy and to introduce "implantogenomics" for the first time.