Protection and Isolation of Bioorthogonal Metal Catalysts by Using Monolayer-Coated Nanozymes

Chembiochem. 2020 Oct 1;21(19):2759-2763. doi: 10.1002/cbic.202000207. Epub 2020 Jun 22.

Abstract

We demonstrate here the protection of biorthogonal transition metal catalysts (TMCs) in biological environments by using self-assembled monolayers on gold nanoparticles (AuNPs). Encapsulation of TMCs in this hydrophobic environment preserves catalytic activity in presence of pH conditions and complex biological media that would deactivate free catalyst. Significantly, the protection affords by these nanozymes extends to isolation of the catalyst active site, as demonstrated by the independence of rate over a wide pH range, in strong contrast to the behavior of the free catalyst.

Keywords: bioorthogonal catalysis; insulation; monolayers; nanozymes; protection.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Catalysis
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry*
  • Hydrogen-Ion Concentration
  • Hydrophobic and Hydrophilic Interactions
  • Metals, Heavy / chemistry*
  • Metals, Heavy / isolation & purification
  • Molecular Structure
  • Nanostructures / chemistry*
  • Particle Size

Substances

  • Coordination Complexes
  • Metals, Heavy