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Ann Neurol. 1988 Oct;24(4):574-6.

Rate of cell death in parkinsonism indicates active neuropathological process.

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1
Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada.

Abstract

It has been hypothesized that idiopathic parkinsonism might be due to age-related attrition of dopamine neurons occurring long after an initial acute episode. We present evidence against this hypothesis, based on our finding of at least six times as many HLA-DR-positive microglia phagocytosing dopamine neurons in parkinsonian brains as in control brains. This difference indicates an active pathological process.

PMID:
3239957
DOI:
10.1002/ana.410240415
[Indexed for MEDLINE]
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