Role of opiates in the regulation of water and salt metabolism: effects of the FK 33-824 injection into the subfornical organ of both normal and hypophysectomized rats

J B Fregoneze; E Castro-e-Silva; M M Valença; J Antunes-Rodrigues

Role of opiates in the regulation of water and salt metabolism: effects of the FK 33-824 injection into the subfornical organ of both normal and hypophysectomized rats

Braz J Med Biol Res. 1988;21(3):641-4.

Authors

J B Fregoneze¹, E Castro-e-Silva, M M Valença, J Antunes-Rodrigues

Affiliation

¹ Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, USP, Brasil.

PMID: 3228651

Abstract

The present study was performed to evaluate the participation of the subfornical organ (SFO) in the opioid modulation of urinary volume (Uv), and of sodium and potassium excretion. Intact and hypophysectomized (HYPOX) adult male rats were implanted with a cannula into the SFO, and injected with the opiate agonist FK 33-824 (FK). FK induced a significant decrease in Uv and in Na+ and K+ excretion in both intact and HYPOX rats. The data show that opioids play an important role in the regulation of hydromineral metabolism by the SFO.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
D-Ala(2),MePhe(4),Met(0)-ol-enkephalin / pharmacology*
Diuresis / drug effects*
Hypophysectomy
Male
Neurosecretory Systems / physiology*
Potassium / urine*
Rats
Rats, Inbred Strains
Sodium / urine*
Subfornical Organ / physiology*

Substances

D-Ala(2),MePhe(4),Met(0)-ol-enkephalin
Sodium
Potassium