A toxic palmitoylation of Cdc42 enhances NF-κB signaling and drives a severe autoinflammatory syndrome

Affiliations

• ¹ Institut Imagine, INSERM U1163, CNRS ERL 8254, Université Paris Descartes, Sorbonne Paris-Cité, Laboratoire d'Excellence GR-Ex, Paris, France.
• ² Université de Paris, Institut Cochin, INSERM, U1016, CNRS, UMR8104, Paris, France.
• ³ Cell Polarity, Migration and Cancer Unit, Institut Pasteur, UMR3691 CNRS, Equipe Labellisée Ligue Contre le Cancer, Paris, France; Sorbonne Université, Collège doctoral, F-75005 Paris, France.
• ⁴ Global Health Institute, School of Life Sciences, EPFL, Lausanne, Switzerland.
• ⁵ Department of Dermatology, Reference Center for Genodermatoses (MAGEC), Necker- Enfants Malades Hospital (AP-HP), Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France.
• ⁶ Institut Curie, PSL Research University, Centre de Recherche, Laboratoire de Spectrométrie de Masse Protéomique, Paris, France.
• ⁷ Cell Polarity, Migration and Cancer Unit, Institut Pasteur, UMR3691 CNRS, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
• ⁸ Fédération de Génétique, Service de Génétique Moléculaire, Hôpital Necker-Enfants Malades, Paris, France.
• ⁹ Institut Imagine, INSERM U1163, CNRS ERL 8254, Université Paris Descartes, Sorbonne Paris-Cité, Laboratoire d'Excellence GR-Ex, Paris, France; Department of Pathology, Necker Enfants Malades, Université de Paris, Paris, France.
• ¹⁰ Department of Pathology, reference centre MAGEC, Necker-Enfants Malades Hospital, APHP, Paris, France.
• ¹¹ Unité d'Immunologie Hématologie Rhumatologie Pédiatrique, Necker-Enfants Malades Hospital (AP-HP5), Paris Descartes-Sorbonne Paris Cité University, Paris, France.
• ¹² Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Descartes University, Imagine Institute, Paris, France.
• ¹³ Laboratoire de Biologie et Pharmacologie Appliquée, CNRS and Ecole Normale Supérieure Paris-Saclay, Cachan, France.
• ¹⁴ Institut Imagine, INSERM U1163, CNRS ERL 8254, Université Paris Descartes, Sorbonne Paris-Cité, Laboratoire d'Excellence GR-Ex, Paris, France; Department of Hematology, Hôpital Necker AP-HP, Paris, France.
• ¹⁵ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Descartes University, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, Howard Hughes Medical Institute, New York, NY; Department of Pediatric Immunology and Hematology, Necker-Enfants Malades Hospital (AP-HP), Paris Descartes-Sorbonne Paris Cité University, Paris, France.
• ¹⁶ Department of Dermatology, Reference Center for Genodermatoses (MAGEC), Necker- Enfants Malades Hospital (AP-HP), Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France. Electronic address: christine.bodemer@aphp.fr.
• ¹⁷ Institut Imagine, INSERM U1163, CNRS ERL 8254, Université Paris Descartes, Sorbonne Paris-Cité, Laboratoire d'Excellence GR-Ex, Paris, France. Electronic address: asma.smahi@inserm.fr.
• ¹⁸ Université de Paris, Institut Cochin, INSERM, U1016, CNRS, UMR8104, Paris, France. Electronic address: jerome.delon@inserm.fr.