Format

Send to

Choose Destination
Proteins. 1988;4(2):99-122.

Oligopeptide biases in protein sequences and their use in predicting protein coding regions in nucleotide sequences.

Author information

1
Biocomputing Division, European Molecular Biology Laboratory (EMBL), Heidelberg, Federal Republic of Germany.

Abstract

We have examined oligopeptides with lengths ranging from 2 to 11 residues in protein sequences that show no obvious evolutionary relationship. All sequences in the Protein Identification Resource database were carefully classified by sensitive homology searches into superfamilies to obtain unbiased oligopeptide counts. The results, contrary to previous studies, show clear prejudices in protein sequences. The oligopeptide preferences were used to help decide the significance of sequence homologies and to improve the more general methods for detecting protein coding regions within nucleotide sequences.

PMID:
3227018
DOI:
10.1002/prot.340040204
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center