Send to

Choose Destination
Clin Neuropathol. 1988 Nov-Dec;7(6):299-305.

Lewy body disease with and without dementia: a clinicopathological study of 35 cases.

Author information

Psychiatric Research Institute of Tokyo, Japan.


The pathological basis for dementia in Lewy body disease (LBD) remains controversial. While some investigators propose that cortical lesions are responsible, others favor a subcortical basis for this dementia. Brains from 35 patients with LBD (11 demented with diffuse LBD; 12 demented and 12 non-demented with a brainstem type of LBD) were clinicopathologically examined to elucidate the pathological differences between demented and non-demented patients with LBD. In cases of diffuse LBD, the cortical lesions were found to be responsible for the dementia. In some of the cases (25%) with the brainstem type of LBD, the dementia was attributed to an Alzheimer pathology, while in many cases (75%), degeneration in the subcortical nuclei, mainly the nucleus basalis of Meynert, played a major role in the dementia.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center