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Acta Pathol Jpn. 1988 Nov;38(11):1369-75.

Spontaneous hepatitis in Long-Evans rats. A potential animal model for fulminant hepatitis in man.

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  • 1Laboratory of Pathology, Hokkaido University School of Medicine, Sapporo, Japan.


Spontaneous hepatitis associated with severe jaundice occurred in 90% of an inbred strain of Long-Evans rats. The rapidly progressive syndrome was characterized by abrupt onset, hyperbilirubinemia and increased serum levels of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase, associated with massive and multifocal necrosis of the liver. This strain should provide a useful animal model for analysis of the pathogenesis of fulminant hepatitis in humans.

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