To evaluate the feasibility of analyzing large perinatal datasets on smaller computers, the 1980 National Natality Survey was downloaded first to a minicomputer and then to a microcomputer. Operating system utilities were used to minimize programming and storage requirements. Accuracy was confirmed by comparing descriptive statistics with published values derived on mainframes. Based on a typical analytic problem, implementation on the microcomputer compared favorably to implementation on the minicomputer. Our results suggest that the microcomputer may be a practical alternative to the mainframe for perinatal epidemiological analysis.