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Cell Biochem Funct. 2020 Mar 24. doi: 10.1002/cbf.3527. [Epub ahead of print]

Ubiquitin carboxy-terminal hydrolase L1 - physiology and pathology.

Author information

1
Pediatric Surgery Department, Medical University of Bialystok, Bialystok, Poland.
2
Biophysics Department, Medical University of Bialystok, Bialystok, Poland.

Abstract

Ubiquitin C-terminal hydrolase 1 (UCHL1) is an enzyme unique for its multiple activity - both ligase and hydrolase. UCHL1 was first identified as an abundant protein found in the brain and testes, however its expression is not limited to the neuronal compartment. UCHL1 is also highly expressed in carcinomas of various tissue origins, including those from brain, lung, breast, kidney, colon, prostate, pancreas and mesenchymal tissues. Loss-of-function studies and an inhibitor for UCHL1 confirmed the importance of UCHL1 for cancer therapy. So far biological significance of UCHL1 was described in the following processes: spermatogenesis, oncogenesis, angiogenesis, cell proliferation and differentiation in skeletal muscle, inflammation, tissue injury, neuronal injury and neurodegeneration.

KEYWORDS:

UCHL1; human; ubiquitin carboxy-terminal hydrolase L1

PMID:
32207552
DOI:
10.1002/cbf.3527

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