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Interdiscip Toxicol. 2019 Oct;12(2):89-92. doi: 10.2478/intox-2019-0010. Epub 2020 Feb 20.

Probiotics against alleviation of lead toxicity: recent advances.

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West Bengal Medical Services Corporation Ltd., GN 29, Sector V, Salt Lake City, Kolkata 700091, West Bengal, India.


Lead is a toxic heavy metal and there is no specific, safe and efficacious therapeutic management of lead toxicity. Scientific literature reported that some probiotic microorganisms alleviated experimentally induced lead toxicity. The present review attempts to collate the experimental studies on probiotics with ameliorative effects. Literature survey revealed that four (4) types of probiotic microorganisms exhibited significant protection from lead toxicity in experimental pre-clinical studies. No clinical study with significant outcome was found in the literature. From the outcomes of the preclinical studies it appears that probiotics are prospective for alleviation and treatment of lead toxicity.


lactobacilli; lead; oxidative stress; probiotics

Conflict of interest statement

The author reports no conflict of interest. The author alone is responsible for the content and writing of this paper.

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