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Antimicrob Agents Chemother. 2020 Mar 23. pii: AAC.00440-20. doi: 10.1128/AAC.00440-20. [Epub ahead of print]

Tilorone: A Broad-Spectrum Antiviral For Emerging Viruses.

Author information

1
Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, NC27606, USA sean@collaborationspharma.com peter.madrid@sri.com.
2
SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA. sean@collaborationspharma.com peter.madrid@sri.com.

Abstract

Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in vivo against the Ebola Virus. After a broad screening of additional viruses, we now describe in vitro activity against Chikungunya virus (CHIK) and Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).

PMID:
32205350
DOI:
10.1128/AAC.00440-20

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