Format

Send to

Choose Destination
Res Social Adm Pharm. 2020 Feb 12. pii: S1551-7411(19)30530-3. doi: 10.1016/j.sapharm.2020.02.004. [Epub ahead of print]

Development of a community pharmacy-based intervention to enhance adherence to adjuvant endocrine therapy among breast cancer survivors guided by the Intervention Mapping approach.

Author information

1
Faculty of Pharmacy, Université Laval, Québec, QC, Canada; CHU de Québec-Université Laval Research Center, Population Health and Optimal Health Practices Axis, Québec, QC, Canada; CHU de Québec-Université Laval Research Center, Oncology Axis, Québec, QC, Canada; Équipe de Recherche Michel-Sarrazin en Oncologie Psychosociale et Soins Palliatifs (ERMOS), Québec, QC, Canada.
2
CHU de Québec-Université Laval Research Center, Population Health and Optimal Health Practices Axis, Québec, QC, Canada; Faculty of Nursing, Université Laval, Québec, QC, Canada.
3
Faculty of Pharmacy, Université Laval, Québec, QC, Canada; CHU de Québec-Université Laval Research Center, Oncology Axis, Québec, QC, Canada; Centre des Maladies du Sein, CHU de Québec-Université Laval, Québec, QC, Canada.
4
Faculty of Pharmacy, Université Laval, Québec, QC, Canada; CHU de Québec-Université Laval Research Center, Oncology Axis, Québec, QC, Canada; Équipe de Recherche Michel-Sarrazin en Oncologie Psychosociale et Soins Palliatifs (ERMOS), Québec, QC, Canada; Centre des Maladies du Sein, CHU de Québec-Université Laval, Québec, QC, Canada; Centre intégré de santé et des services sociaux (CISSS) de Chaudière-Appalaches Research Center, Québec, QC, Canada.
5
Faculty of Pharmacy, Université Laval, Québec, QC, Canada; CHU de Québec-Université Laval Research Center, Oncology Axis, Québec, QC, Canada; Équipe de Recherche Michel-Sarrazin en Oncologie Psychosociale et Soins Palliatifs (ERMOS), Québec, QC, Canada; Faculty of Medicine, Department of Social and Preventive Medicine, Université Laval, Québec, QC, Canada; Centre de recherche en épidémiologie et santé des populations, INSERM U. 1018, Villejuif, France.
6
CHU de Québec-Université Laval Research Center, Oncology Axis, Québec, QC, Canada; Centre des Maladies du Sein, CHU de Québec-Université Laval, Québec, QC, Canada.
7
Faculty of Pharmacy, Université Laval, Québec, QC, Canada; CHU de Québec-Université Laval Research Center, Population Health and Optimal Health Practices Axis, Québec, QC, Canada; Équipe de Recherche Michel-Sarrazin en Oncologie Psychosociale et Soins Palliatifs (ERMOS), Québec, QC, Canada; Centre des Maladies du Sein, CHU de Québec-Université Laval, Québec, QC, Canada. Electronic address: sophie.lauzier@pha.ulaval.ca.

Abstract

BACKGROUND:

Adjuvant endocrine therapy (AET) is prescribed for 5 or 10 years to women with non-metastatic breast cancer to reduce recurrence and mortality risks. However, AET adherence is suboptimal for many women. The few interventions specifically designed to enhance AET adherence and evaluated to date have provided inconclusive results. None of these interventions was offered in the community pharmacy setting.

OBJECTIVE:

To describe the development of the PAcHA program, a community pharmacy-based intervention aiming to enhance AET adherence.

METHODS:

The development of the intervention was guided by the six-step Intervention Mapping approach: needs assessment (Step 1); development of objectives matrices (Step 2); selection of theory-based intervention methods and practical applications (Step 3); development of the intervention program (Step 4); development of the adoption and implementation plan (Step 5); and evaluation plan (Step 6). Researchers, pharmacists and women prescribed AET were consulted at key steps.

RESULTS:

The logic model was developed based on women's needs identified through a literature review and a qualitative study (Step 1). Optimal use of treatment for each woman with a new AET prescription was considered the behavioral outcome of the intervention. A woman is expected to: acquire knowledge about AET; make an informed decision about AET initiation and persistence; respect administration modalities and cope with side effects (Step 2). Motivational interviewing principles serve to guide the pharmacist intervention (Step 3). The intervention is brief and tailored to AET initiation and follow-up visits. Standardized intervention tools are available as support for pharmacists in their counseling (Step 4). An implementation plan was established, and web-based training was designed to train the pharmacists (Step 5). A cluster-randomized controlled trial was designed to evaluate the intervention (Step 6).

CONCLUSION:

The systematic approach used for developing the intervention may increase its potential for being efficiently implemented and effective.

KEYWORDS:

Adjuvant endocrine therapy; Breast cancer; Community pharmacy services; Intervention mapping; Medication adherence; Program development

Conflict of interest statement

Declaration of competing interest The authors declare that there is no potential conflict of interest with respect to the research, authorship, and publication of this article.

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center