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Intractable Rare Dis Res. 2020 Feb;9(1):10-13. doi: 10.5582/irdr.2019.01130.

Advances in stem cell therapy for the treatment of Peyronie's disease.

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Department of Urology, Zahraa Hospital, University Medical Center, Lebanese University, Beirut, Lebanon.
Department of Urology, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon.
Clinic of Dermatology, Dr. Brinkmann, Schult & Samimi-Fard, Gladbeck, Germany.


Peyronie's disease (PD) is a connective tissue disorder of the penis characterized by fibrosis and plaque formation within the tunica albuginea. PD is characterized by painful penile curvature that impairs sexual intercourse. Stem cell therapy is one of the recent non-invasive treatment options for patients with PD and it has promising results. Stem cells are undifferentiated cells that are capable of self-renewal and differentiation, promoting the repair of tissues via their immunomodulatory and anti-inflammatory action. Adipose-derived stem cells (ADSC) are used most widely due to their abundant tissue source and ease of isolation. Multiple studies have indicated the efficacy of stem cell therapy as a potential treatment for fibrotic diseases. Clearly, ADSCs may represent a way to treat and prevent PD in both rat and human models. Further clinical studies are needed to confirm the efficacy of stem cell therapy for PD in humans.


Peyronie's disease; adipose stem cells; fibrosis; regeneration; stem cell

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