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Cereb Cortex. 2020 Mar 20. pii: bhaa035. doi: 10.1093/cercor/bhaa035. [Epub ahead of print]

Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes.

Author information

1
The Hospital for Sick Children, University of Toronto, Toronto, M5G 0A4 ON, M5G 0A4, Canada.
2
Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, University of Toronto, Toronto, M4G 1R8 ON, Canada.
3
Department of Genetics, Yale University School of Medicine, New Haven, 06510 CT, USA.
4
Department of Neuroscience, Yale University School of Medicine, New Haven, 06510 CT, USA.
5
Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, 8036 Graz, Austria.
6
Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria.
7
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.
8
Department of Medical Informatics, Erasmus MC, 3015 Rotterdam, The Netherlands.
9
Department of Epidemiology, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.
10
Department of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, 06510 CT, USA.
11
Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, 77030 Houston, 77030 TX, USA.
12
Johns Hopkins School of Medicine, Baltimore, 21205 MD, USA.
13
University of Mississippi Medical Center, Jackson, 39216 MS, USA.
14
Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, 8036 Graz, Austria.
15
Language and Genetics Department, Max Planck Institute for Psycholinguistics, 6525 Nijmegen, The Netherlands.
16
Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, Centre National de la Recherche Scientifique, Commissariat à l'Energie Atomique, et Université de Bordeaux, F-33000 Bordeaux, France.
17
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101 WA, USA.
18
Department of Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.
19
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, EH8 9YL Edinburgh, UK.
20
Department of Psychology, University of Edinburgh, EH8 9JZ Edinburgh, UK.
21
Montreal Neurological Institute, McGill University, H3A 2B4 Montreal, QC, Canada.
22
Centre for Clinical Brain Sciences, University of Edinburgh, EH8 9YL Edinburgh, UK.
23
Division of Psychiatry, University of Edinburgh, EH8 9JZ Edinburgh, UK.
24
UK Dementia Research Institute, University of Edinburgh, EH8 9JZ Edinburgh, UK.
25
Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04109 Leipzig, Germany.
26
LIFE Research Center for Civilization Diseases, 04103 Leipzig, Germany.
27
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.
28
Faculty of Medicine, CRC 1052 Obesity Mechanisms, University of Leipzig, 04109 Leipzig, Germany.
29
Day Clinic for Cognitive Neurology, University Hospital Leipzig, 04103 Leipzig, Germany.
30
Mathematics and Statistics, Murdoch University, 6150 Perth, WA, Australia.
31
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.
32
Neuroscience Research Australia, 2031 Sydney, NSW, Australia.
33
National Ageing Research Institute, Royal Melbourne Hospital, 3052 Melbourne, VIC, Australia.
34
Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, 3010 Melbourne, VIC, Australia.
35
Brain and Mind Centre, The University of Sydney, 2050 Sydney, NSW, Australia.
36
School of Medical Sciences, University of New South Wales, 2052 Sydney, NSW, Australia.
37
Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, 2031 Sydney, NSW, Australia.
38
Queensland Brain Institute, The University of Queensland, 4072 St Lucia, QLD, Australia.
39
Centre for Advanced Imaging, The University of Queensland, 4072 St Lucia, QLD, Australia.
40
Dementia Centre for Research Collaboration, University of New South Wales, 2052 Sydney, NSW, Australia.
41
Neuropsychiatric Institute, Prince of Wales Hospital, 2031 Sydney, NSW, Australia.
42
Department of Neurology, Erasmus MC University Medical Centre, 3015 Rotterdam, The Netherlands.
43
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17489 Greifswald, Germany.
44
44German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, 37075, Germany.
45
Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, 17489 Greifswald, Germany.
46
Inserm, Bordeaux Population Health Research Center, University of Bordeaux, Team VINTAGE, UMR 1219, F-33000 Bordeaux, France.
47
Department of Neurology, CHU de Bordeaux, F-33000 Bordeaux, France.
48
Institut des Maladies Neurodégénratives, UMR 5293, CEA, CNRS, University of Bordeaux, Ubordeaux, F-33000 Bordeaux, France.
49
Department of Neurology, Boston University School of Medicine, Boston, 02118 MA, USA.
50
Virginia Institute for Psychiatric and Behavioural Genetics, Virginia Commonwealth University, Richmond, 23284 VA, USA.
51
Department of Psychiatry, University of California, San Diego, 92093 CA, USA.
52
Center for Behavior Genetics of Aging, University of California, San Diego, 92093 CA, USA.
53
VA San Diego Center of Excellence for Stress and Mental Health, San Diego, 92161 CA, USA.
54
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, 90033 CA, USA.
55
Department of Physiology, University of Toronto, Toronto, M5S 1A8 ON, Canada.
56
Department of Nutritional Sciences, University of Toronto, Toronto, M5S 1A8 ON, Canada.
57
55Department of Epidemiology and Biostatistics, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, 78229 TX, USA.
58
Department of Psychology, University of Toronto, Toronto, M5S 3G3 ON, Canada.
59
Department of Psychiatry, University of Toronto, Toronto, M5T 1R8 ON, Canada.

Abstract

We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade-albeit in a very limited manner-to behaviors as complex as the choice of one's occupation.

KEYWORDS:

brain development; cortical surface area; cortical thickness; genome-wide association study; occupational aptitude

PMID:
32198502
DOI:
10.1093/cercor/bhaa035

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