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Curr Biol. 2020 Mar 13. pii: S0960-9822(20)30277-3. doi: 10.1016/j.cub.2020.02.070. [Epub ahead of print]

Vision and Locomotion Combine to Drive Path Integration Sequences in Mouse Retrosplenial Cortex.

Author information

1
Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB T1K 3M4, Canada; Neuro-Electronics Research Flanders, Kapeldreef 75, Leuven 3001, Belgium. Electronic address: zjumao@gmail.com.
2
Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB T1K 3M4, Canada.
3
Neuro-Electronics Research Flanders, Kapeldreef 75, Leuven 3001, Belgium; VIB, Leuven 3000, Belgium; Department of Biology and Leuven Brain Institute, KU Leuven, Naamsestraat 59-Box 2465, Leuven 3000, Belgium. Electronic address: vincent.bonin@nerf.be.
4
Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB T1K 3M4, Canada; Department of Neurobiology and Behavior, 2205 McGaugh Hall, University of California, Irvine, CA 92697, USA. Electronic address: bruce.mcnaughton@uleth.ca.

Abstract

The retrosplenial cortex (RSC) is involved in a broad range of cognitive functions, integrating rich sensory, motor, and spatial signals from multiple brain areas, including the hippocampal system. RSC neurons show hippocampus-dependent activity reminiscent of place cell sequences. Using cellular calcium imaging in a virtual reality (VR)-based locomotion task, we investigate how the integration of visual and locomotor inputs may give rise to such activity in RSC. A substantial population shows neural sequences that track position in the VR environment. This activity is driven by the conjunction of visual stimuli sequences and active movement, which is suggestive of path integration. The activity is anchored to a reference point and predominantly follows the VR upon manipulations of optic flow against locomotion. Thus, locomotion-gated optic flow, combined with the presence of contextual cues at the start of each trial, is sufficient to drive the sequential activity. A subpopulation shows landmark-related visual responses that are modulated by animal's position in the VR. Thus, rather than fragmenting the spatial representation into equivalent locomotion-based ensemble versus optic-flow-based ensemble, in RSC, optic flow appears to override locomotion signals coherently in the population, when the gain between the two signals is altered.

KEYWORDS:

locomotion; neural sequences; optic flow; path integration; reference points; retrosplenial cortex; self-motion; task encoding; visual landmarks

PMID:
32197086
DOI:
10.1016/j.cub.2020.02.070

Conflict of interest statement

Declaration of Interests The authors declare no competing financial interests.

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