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Front Microbiol. 2020 Mar 5;11:361. doi: 10.3389/fmicb.2020.00361. eCollection 2020.

Single-Cell Analysis of Foot-and-Mouth Disease Virus.

Wang H1,2, Xin X3, Zheng C1,4, Shen C1,4.

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State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.
Center for Experimental Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Institute of Pathogenic Microorganism and College of Bioscience and Engineering, Jiangxi Agricultural University, Nanchang, China.
China Center for Type Culture Collection, Wuhan University, Wuhan, China.


With the rapid development of single-cell technologies, the mechanisms underlying viral infections and the interactions between hosts and viruses are starting to be explored at the single-cell level. The foot-and-mouth-disease (FMD) virus (FMDV) causes an acute and persistent infection that can result in the break-out of FMD, which can have serious effects on animal husbandry. Single-cell techniques have emerged as powerful approaches to analyze virus infection at the resolution of individual cells. In this review, the existing single-cell studies examining FMDV will be systematically summarized, and the central themes of these studies will be presented.


FMDV; heterogeneity; isolation; persistent infection; single-cell

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