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Front Microbiol. 2020 Mar 5;11:361. doi: 10.3389/fmicb.2020.00361. eCollection 2020.

Single-Cell Analysis of Foot-and-Mouth Disease Virus.

Wang H1,2, Xin X3, Zheng C1,4, Shen C1,4.

Author information

1
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.
2
Center for Experimental Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, China.
3
Institute of Pathogenic Microorganism and College of Bioscience and Engineering, Jiangxi Agricultural University, Nanchang, China.
4
China Center for Type Culture Collection, Wuhan University, Wuhan, China.

Abstract

With the rapid development of single-cell technologies, the mechanisms underlying viral infections and the interactions between hosts and viruses are starting to be explored at the single-cell level. The foot-and-mouth-disease (FMD) virus (FMDV) causes an acute and persistent infection that can result in the break-out of FMD, which can have serious effects on animal husbandry. Single-cell techniques have emerged as powerful approaches to analyze virus infection at the resolution of individual cells. In this review, the existing single-cell studies examining FMDV will be systematically summarized, and the central themes of these studies will be presented.

KEYWORDS:

FMDV; heterogeneity; isolation; persistent infection; single-cell

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