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J Bone Metab. 2020 Feb;27(1):27-34. doi: 10.11005/jbm.2020.27.1.27. Epub 2020 Feb 29.

Risk of Osteoporotic Fracture in Patients with Breast Cancer: Meta-Analysis.

Author information

1
Department of Surgery, Center for Breast Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
2
Department of Orthopaedic Surgery, Gyeongsang National University Hospital, Jinju, Korea.
3
Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
4
Department of Orthopaedic Surgery, Chung-Ang University College of Medicine, Seoul, Korea.

Abstract

Background:

The fracture risk induced by anti-estrogen therapy in patients with breast cancer remains controversial. The aim of this study was to perform a meta-analysis and systematic review to evaluate the risk of osteoporotic fracture in patients with breast cancer.

Methods:

A systematic search was performed to identify studies that included any osteoporotic fracture (hip fracture and vertebral fracture) in patients breast cancer. Main outcome measures were occurrence and risk of osteoporotic fractures including hip and vertebral fractures in patients and controls.

Results:

A systematic search yielded a total of 4 studies that included osteoporotic fracture outcomes in patients with breast cancer. Meta-analysis showed a higher risk of osteoporotic fracture in patients with breast cancer. Analysis of these 4 studies involving a total of 127,722 (23,821 cases and 103,901 controls) patients showed that the incidence of osteoporotic fractures was higher in the breast cancer group than in the control group. The pooled estimate of crude relative risk for osteoporotic fracture was 1.35 (95% confidence interval, 1.29-1.42; P<0.001).

Conclusions:

Although studies were limited by a small number, results suggested a possible association between anti-estrogen therapy and increased risk of osteoporotic fractures in patients with breast cancer.

KEYWORDS:

Breast neoplasms; Hip fractures; Osteoporotic fractures; Spinal fractures

Conflict of interest statement

Conflict of interest: No potential conflict of interest relevant to this article was reported.

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