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Neurol India. 2020 Mar 19. doi: 10.4103/0028-3886.280647. [Epub ahead of print]

Tumors Masquerading as Neurological Diseases: A Caution for Clinicians in Planning Diagnosis and Treatment.

Author information

1
Department of Pediatrics Surgery, Govt TD Medical College, Alapuzha, Kerala, India.
2
Department of Neurology, NIMHANS, Bangalore, Karnataka, India.
3
Sri Avittam Thirunal Hospital, Medical College, Trivandrum, Kerala, India.
4
Department of Radiology, NIMHANS, Bangalore, Karnataka, India.

Abstract

Introduction:

Neurological diseases can be due to direct diseases of the central nervous system (CNS) or peripheral nervous system (PNS) or be a bystander syndrome of systemic diseases. Treatment options depend on the cause. Toxic, metabolic and nutritional, and immune-mediated consequences of clinically occult neoplasms produce a spectrum of neurological diseases, recognition of which has therapeutic and prognostic importance.

Patients and Methods:

Children, as well as adults who presented to the authors in the last 5 years with neurological diseases and later their diseases could be diagnosed or attributed to neoplasms which were occult, were included for the study.

Observation:

28 patients were seen by the authors in the last 5 years with neurological manifestation and hidden tumor. Maximum incidence was in the age of above 60 years followed by the age group of 21-40 years. The commonest neurological presentation was muscle and nerve in adults and seizure in children.

Discussion:

Short duration, rapid progression, severe weight loss, and poor response to treatment given for nontumor associated neurological syndrome are the red flags which point to the diagnosis.

Conclusion:

Seizures and psychosis formed the commonest features in children, muscle and nerve in adults. Short duration, rapid progression, and resistance to treatment are the markers for possible underlying neoplasm.

KEYWORDS:

Mass lesions; TRIAD; prognostic and therapeutic relevance; treatment-resistant neurology

PMID:
32189708
DOI:
10.4103/0028-3886.280647
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