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Neurol India. 2020 Mar 19. doi: 10.4103/0028-3886.280633. [Epub ahead of print]

Application Value of 3.0-T Multivoxel 1H-MR Spectroscopy in the Peritumoral Tissue of Brain Astrocytic Tumors.

Author information

Department of Radiology, Longyan First Hospital, Fujian Medical University, Longyan, Fujian, China.
Department of Neurosurgery, Longyan First Hospital, Fujian Medical University, Longyan, Fujian, China.



This study aimed to explore metabolic features in the peritumoral tissue of different-rank brain astrocytic tumors using multivoxel proton magnetic resonance spectroscopy (1H-MRS) and to estimate its application value in the MRS quantitative ratio of brain astrocytic tumors.

Materials and Methods:

A total of 82 patients with brain astrocytic tumors, confirmed by postoperative pathological evaluation, were divided into low-grade astrocytic tumors [World Health Organization (WHO) grade I-II; 32 cases] and high-grade astrocytic tumors (WHO grade III-IV; 50 cases). The semi-quantitative and relative quantitative metabolite ratios of the parenchyma area, peritumoral tissue area, and normal area were measured. The P value was set as <0.05.


The relative quantitative ratios of choline (Cho)/creatine (Cr) and Cho/N-acetyl aspartate (NAA) significantly differed in the peritumoral tissues of the high-grade astrocytic tumors and low-grade astrocytic tumors (P < 0.05), but NAA/Cr showed no significant difference.


The changes in the metabolite ratio of the peritumoral tissue area in brain astrocytic tumors reflect the biological behavior of different tumors. They have a significant clinical value in classifying brain astrocytic tumors and indicating the scope of invasion.


Astrocytoma; brain neoplasms; magnetic resonance spectroscopy

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