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Neurol India. 2020 Mar 19. doi: 10.4103/0028-3886.280633. [Epub ahead of print]

Application Value of 3.0-T Multivoxel 1H-MR Spectroscopy in the Peritumoral Tissue of Brain Astrocytic Tumors.

Author information

1
Department of Radiology, Longyan First Hospital, Fujian Medical University, Longyan, Fujian, China.
2
Department of Neurosurgery, Longyan First Hospital, Fujian Medical University, Longyan, Fujian, China.

Abstract

Objective:

This study aimed to explore metabolic features in the peritumoral tissue of different-rank brain astrocytic tumors using multivoxel proton magnetic resonance spectroscopy (1H-MRS) and to estimate its application value in the MRS quantitative ratio of brain astrocytic tumors.

Materials and Methods:

A total of 82 patients with brain astrocytic tumors, confirmed by postoperative pathological evaluation, were divided into low-grade astrocytic tumors [World Health Organization (WHO) grade I-II; 32 cases] and high-grade astrocytic tumors (WHO grade III-IV; 50 cases). The semi-quantitative and relative quantitative metabolite ratios of the parenchyma area, peritumoral tissue area, and normal area were measured. The P value was set as <0.05.

Results:

The relative quantitative ratios of choline (Cho)/creatine (Cr) and Cho/N-acetyl aspartate (NAA) significantly differed in the peritumoral tissues of the high-grade astrocytic tumors and low-grade astrocytic tumors (P < 0.05), but NAA/Cr showed no significant difference.

Conclusions:

The changes in the metabolite ratio of the peritumoral tissue area in brain astrocytic tumors reflect the biological behavior of different tumors. They have a significant clinical value in classifying brain astrocytic tumors and indicating the scope of invasion.

KEYWORDS:

Astrocytoma; brain neoplasms; magnetic resonance spectroscopy

PMID:
32189694
DOI:
10.4103/0028-3886.280633
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