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Am J Transplant. 2020 Mar 17. doi: 10.1111/ajt.15869. [Epub ahead of print]

Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression.

Zhu L1,2, Xu X3, Ma K4, Yang J5, Guan H6, Chen S1,2, Chen Z1,2, Chen G1,2.

Author information

1
Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
2
Key Laboratory of Organ Transplantation, Ministry of Education, Ministry of Public Health, Chinese Academy of Medical Sciences, Wuhan, China.
3
Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
4
Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
5
Department of Respiratory Medicine, Second Hospital of Jilin University, Changchun, China.
6
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Abstract

The current outbreak of Coronavirus Disease 2019 (COVID-19) has raised great concern worldwide, but its impact on transplant recipients is unknown. We report here the clinical features and therapeutic course of the first reported renal transplant recipient with confirmed COVID-19 pneumonia. This is a 52-year-old man who received kidney transplantation 12 years ago. His overall clinical characteristics (symptoms, laboratory examinations, and chest CT) were similar to those of non-transplanted COVID-19 patients. Following a treatment regimen consisting of reduced immunosuppressant use and low dose methylprednisolone-based therapy, the COVID-19 pneumonia in this long-term immunosuppressive patient was successfully recovered. This effectively treated case has reference value for the future treatment of other transplant patients with COVID-19 pneumonia.

KEYWORDS:

COVID-19; coronavirus; immunosuppression; pneumonia; renal transplantation

PMID:
32181990
DOI:
10.1111/ajt.15869

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