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Proteomics. 2020 Mar 17:e1900228. doi: 10.1002/pmic.201900228. [Epub ahead of print]

Single-cell RNA Sequencing in Hematological Diseases.

Zhu Y1,2, Huang Y1,2, Tan Y1,3, Zhao W1,2, Tian Q1,3.

Author information

1
Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital.
2
Shanghai Institute of Hematology.
3
National Research Center for Translational Medicine (Shanghai).

Abstract

Hematological diseases, including leukemia, lymphoma and multiple myeoloma, are characterized by high heterogeneity with diverse cellular subpopulations. Single-cell RNA sequencing (scRNA-seq), a transformational technology, provides deep insights into cell-to-cell variation in tumor and microenvironment, allows high resolution dissection of the pathogenic mechanisms of diseases, and affords potential clinical utilities. We summarize recent development in single cell transcriptomics and associated technologies and their applications in hematological disorders for unraveling cellular subpopulations, disease pathogenesis, patient stratification, and therapeutic responses. This article is protected by copyright. All rights reserved.

KEYWORDS:

CITE-Seq; Haematological Malignancy; Single Cell Analysis; Single Cell RNA-Seq

PMID:
32181578
DOI:
10.1002/pmic.201900228

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