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Clin Chem Lab Med. 2020 Mar 16. pii: /j/cclm.ahead-of-print/cclm-2020-0188/cclm-2020-0188.xml. doi: 10.1515/cclm-2020-0188. [Epub ahead of print]

Prominent changes in blood coagulation of patients with SARS-CoV-2 infection.

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Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, P.R. China.
Department of Clinical Laboratory, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, P.R. China.
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, P.R. China.
Wuhan Institute of Biotechnology, Wuhan, P.R. China.


Background As the number of patients increases, there is a growing understanding of the form of pneumonia sustained by the 2019 novel coronavirus (SARS-CoV-2), which has caused an outbreak in China. Up to now, clinical features and treatment of patients infected with SARS-CoV-2 have been reported in detail. However, the relationship between SARS-CoV-2 and coagulation has been scarcely addressed. Our aim is to investigate the blood coagulation function of patients with SARS-CoV-2 infection. Methods In our study, 94 patients with confirmed SARS-CoV-2 infection were admitted in Renmin Hospital of Wuhan University. We prospectively collect blood coagulation data in these patients and in 40 healthy controls during the same period. Results Antithrombin values in patients were lower than that in the control group (pā€‰<ā€‰0.001). The values of D-dimer, fibrin/fibrinogen degradation products (FDP), and fibrinogen (FIB) in all SARS-CoV-2 cases were substantially higher than those in healthy controls. Moreover, D-dimer and FDP values in patients with severe SARS-CoV-2 infection were higher than those in patients with milder forms. Compared with healthy controls, prothrombin time activity (PT-act) was lower in SARS-CoV-2 patients. Thrombin time in critical SARS-CoV-2 patients was also shorter than that in controls. Conclusions The coagulation function in patients with SARS-CoV-2 is significantly deranged compared with healthy people, but monitoring D-dimer and FDP values may be helpful for the early identification of severe cases.


Corona Virus Disease 2019; SARS-CoV-2; blood coagulation


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