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Microb Pathog. 1988 Sep;5(3):159-67.

Protein serotyping of Streptococcus pneumoniae based on reactivity to six monoclonal antibodies.

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Department of Microbiology, University of Alabama, Birmingham 35294.


Six monoclonal antibodies to proteins of Streptococcus pneumoniae were tested in a dot blot assay for reactivity with 499 clinical isolates of pneumococci. Forty-four percent of the isolates reacted with at least one of the antibodies. Nineteen patterns of reactivity were identified and each designated as a provisional protein serotype. Protein serotyping identified pneumococcal strains independently of their capsular type and made it possible to differentiate strains within most capsular types. A protein serotyping system provides a new dimension to the phenotypic identification of S. pneumoniae and may eventually provide a basis for assessing the population structure of these organisms.

[Indexed for MEDLINE]

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