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Nat Commun. 2020 Mar 12;11(1):1323. doi: 10.1038/s41467-020-15133-y.

Cryptochrome-mediated blue-light signalling modulates UVR8 photoreceptor activity and contributes to UV-B tolerance in Arabidopsis.

Tissot N1,2, Ulm R3,4.

Author information

1
Department of Botany and Plant Biology, Section of Biology, Faculty of Sciences, University of Geneva, 30 Quai E. Ansermet, 1211, Geneva 4, Switzerland.
2
Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva, Geneva, Switzerland.
3
Department of Botany and Plant Biology, Section of Biology, Faculty of Sciences, University of Geneva, 30 Quai E. Ansermet, 1211, Geneva 4, Switzerland. roman.ulm@unige.ch.
4
Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva, Geneva, Switzerland. roman.ulm@unige.ch.

Abstract

UV-B constitutes a critical part of the sunlight reaching the earth surface. The homodimeric plant UV-B photoreceptor UV RESISTANCE LOCUS 8 (UVR8) monomerizes in response to UV-B and induces photomorphogenic responses, including UV-B acclimation and tolerance. REPRESSOR OF UV-B PHOTOMORPHOGENESIS 1 (RUP1) and RUP2 are negative feedback regulators that operate by facilitating UVR8 ground state reversion through re-dimerization. Here we show that RUP1 and RUP2 are transcriptionally induced by cryptochrome photoreceptors in response to blue light, which is dependent on the bZIP transcriptional regulator ELONGATED HYPOCOTYL 5 (HY5). Elevated RUP1 and RUP2 levels under blue light enhance UVR8 re-dimerization, thereby negatively regulating UVR8 signalling and providing photoreceptor pathway cross-regulation in a polychromatic light environment, as is the case in nature. We further show that cryptochrome 1, as well as the red-light photoreceptor phytochrome B, contribute to UV-B tolerance redundantly with UVR8. Thus, photoreceptors for both visible light and UV-B regulate UV-B tolerance through an intricate interplay allowing the integration of diverse sunlight signals.

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