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J Med Virol. 2020 Mar 12. doi: 10.1002/jmv.25757. [Epub ahead of print]

2019 novel coronavirus patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis.

Li LQ1,2,3, Huang T1,2,3, Wang YQ4, Wang ZP5, Liang Y1,2,3, Huang TB1,2,3, Zhang HY1,2,3, Sun W6, Wang Y2,3.

Author information

1
The First Clinical Medical School, Lanzhou University, Lanzhou, China.
2
Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China.
3
Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China.
4
Day Diagnostic Center, Gansu Provincial Hospital, Lanzhou, China.
5
Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, China.
6
Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China.

Abstract

The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID-19 patients for clinical help. The clinical data of COVID-19 patients from December 2019 to February 2020 were retrieved from four databases. We statistically analyzed the clinical symptoms and laboratory results of COVID-19 patients and explained the discharge rate and fatality rate with a single-arm meta-analysis. The available data of 1994 patients in 10 literatures were included in our study. The main clinical symptoms of COVID-19 patients were fever (88.5%), cough (68.6%), myalgia or fatigue (35.8%), expectoration (28.2%), and dyspnea (21.9%). Minor symptoms include headache or dizziness (12.1%), diarrhea (4.8%), nausea and vomiting (3.9%). The results of the laboratory showed that the lymphocytopenia (64.5%), increase of C-reactive protein (44.3%), increase of lactic dehydrogenase (28.3%), and leukocytopenia (29.4%) were more common. The results of single-arm meta-analysis showed that the male took a larger percentage in the gender distribution of COVID-19 patients 60% (95% CI [0.54, 0.65]), the discharge rate of COVID-19 patients was 42% (95% CI [0.29, 0.55]), and the fatality rate was 7% (95% CI [0.04,0.10]).

KEYWORDS:

2019-nCoV; COVID-19; clinical characteristics; discharge rate; fatality rate; meta-analysis

PMID:
32162702
DOI:
10.1002/jmv.25757

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