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J Med Virol. 2020 Mar 12. doi: 10.1002/jmv.25757. [Epub ahead of print]

2019 novel coronavirus patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis.

Li LQ1,2,3, Huang T1,2,3, Wang YQ4, Wang ZP5, Liang Y1,2,3, Huang TB1,2,3, Zhang HY1,2,3, Sun W6, Wang Y2,3.

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The First Clinical Medical School, Lanzhou University, Lanzhou, China.
Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China.
Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China.
Day Diagnostic Center, Gansu Provincial Hospital, Lanzhou, China.
Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, China.
Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China.


The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID-19 patients for clinical help. The clinical data of COVID-19 patients from December 2019 to February 2020 were retrieved from four databases. We statistically analyzed the clinical symptoms and laboratory results of COVID-19 patients and explained the discharge rate and fatality rate with a single-arm meta-analysis. The available data of 1994 patients in 10 literatures were included in our study. The main clinical symptoms of COVID-19 patients were fever (88.5%), cough (68.6%), myalgia or fatigue (35.8%), expectoration (28.2%), and dyspnea (21.9%). Minor symptoms include headache or dizziness (12.1%), diarrhea (4.8%), nausea and vomiting (3.9%). The results of the laboratory showed that the lymphocytopenia (64.5%), increase of C-reactive protein (44.3%), increase of lactic dehydrogenase (28.3%), and leukocytopenia (29.4%) were more common. The results of single-arm meta-analysis showed that the male took a larger percentage in the gender distribution of COVID-19 patients 60% (95% CI [0.54, 0.65]), the discharge rate of COVID-19 patients was 42% (95% CI [0.29, 0.55]), and the fatality rate was 7% (95% CI [0.04,0.10]).


2019-nCoV; COVID-19; clinical characteristics; discharge rate; fatality rate; meta-analysis


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