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Aesthetic Plast Surg. 2020 Mar 9. doi: 10.1007/s00266-020-01663-9. [Epub ahead of print]

Breast Prosthesis Syndrome: Pathophysiology and Management Algorithm.

Author information

1
Corporación Medicoplástica, Hospital Español de México, Av. Ejercito Nacional 613, Piso 7, consultorio 703, Col. Granada, Alcaldía Miguel Hidalgo, 11520, Mexico City, CDMX, Mexico. caravantes.publications@gmail.com.
2
Directorate of Research, Hospital General de Mexico "Dr. Eduardo Liceaga", Mexico City, Mexico.
3
Department of Radiology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
4
Corporación Medicoplástica, Hospital Español de México, Av. Ejercito Nacional 613, Piso 7, consultorio 703, Col. Granada, Alcaldía Miguel Hidalgo, 11520, Mexico City, CDMX, Mexico.
5
Department of Pathology, Hospital Español de México, Mexico City, Mexico.

Abstract

The cosmetic use of devices like prostheses to increase breast volume is nothing new. It is calculated that millions of people have been exposed to silicone in several ways, including breast implants, and since 1964 there has been uncertainty regarding their safety. We did not find in the literature any studies that reported the appearance of a specific immunological disease in patients with silicone breast implants. Furthermore, there are also neither case-control studies nor reports of patients proving that symptoms of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) occurred after the placement of silicone implants nor that the patients had pre-existing symptoms. Several studies link silicone to allergic reactions and the development of systemic autoimmune diseases; however, other studies deny this association. There are currently several theories about the effect of silicone on the body. One theory with greater acceptance proposes an adjuvant effect of silicone on the development of autoimmune diseases in genetically predisposed patients. However, the variety of symptoms occurring in patients who develop these pathologies leads to doubts about the relationship between the adjuvant effects of a silicone prosthesis may have with a specific autoimmune disease or a mix of these diseases. The lack of consensus on this topic obliges a full review of what has already been reported in the literature to integrate the knowledge and propose a focus for new research on this matter. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

KEYWORDS:

ASIA syndrome; Adverse effects; Breast implants; Breast prosthesis implantation; Silicones

PMID:
32152711
DOI:
10.1007/s00266-020-01663-9

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