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Encephale. 1988 Sep-Oct;14(5):339-44.

[Immune status in infantile autism. Correlation between the immune status, autistic symptoms and levels of serotonin].

[Article in French]

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Service de Psychothérapie, l'Enfant et de l'Adolescent, Hôpital Robert Debré, Reims.


In sixteen autistic children high values of IgG and a high level of lymphocyte stimulation with PHA were observed. Principal component analysis showed: 1) a significant correlation between basic lymphocyte mitogenic activity and the clinical symptoms opposition and hyperactivity, 2) a significant correlation between high Ig levels, high PHA stimulation responses and the main autistic symptoms (withdrawal, inaffectivity, hypoactivity, mannerism, stereotypy and negatively echolalia), 3) a significant correlation with serotonin uptake by platelets and high immunological responses. Such correlations are strongly in favor of an immunologic component in autistic disease.

[Indexed for MEDLINE]

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