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Pediatr Emerg Care. 2020 Mar 3. doi: 10.1097/PEC.0000000000001914. [Epub ahead of print]

Treatment Outcomes of Pediatric Status Epilepticus in a Tertiary Pediatric Intensive Care Unit.

Author information

1
From the Department of Pediatric Neurology, Faculty of Medicine, Afyon Kocatepe University, Afyon.
2
Department of Paediatrics, Liv Hospital, Istinye University, Istanbul.
3
Department of Pediatric Neurology, Tepecik Training and Investigation Hospital, Faculty of Medicine, Izmir Katip Celebi University, Izmir.
4
Department of Pediatric Intensive Care, Denizli Public Hospital, Denizli.
5
Department of Pediatric Intensive Care, Faculty of Medicine, Izmir Katip Celebi University.
6
Department of Pediatric Neurology, Tepecik Training and Investigation Hospital, Izmir, Turkey.

Abstract

OBJECTIVE:

Status epilepticus is associated with high rates of morbidity and mortality; thus, early diagnosis and proper treatment are crucial. We aimed to study the etiology, clinical features, and treatment among pediatric patients with convulsive status epilepticus.

METHODS:

The medical records of 100 patients were retrospectively obtained from pediatric intensive care unit. Etiology, clinical features, and treatment were interpreted by using Fisher exact test, χ test, and Spearman ρ correlation coefficient.

RESULTS:

Seizures had stopped with the first-, second-, and third-line treatment in 29%, 36%, and 35% of the patients, respectively. Only phenytoin treatment was efficient; it has 32.3% rate in second-line treatment. Whereas mortality rate was 10%, morbidity rate was 14% during the follow-up. Epilepsy, hemiparesis, spastic tetraparesis, and mental retardation developed. Mortality was significantly much more in the patients with refractory seizure and cerebral palsy. Development of mental retardation was much higher in the male sex.

CONCLUSIONS:

Phenytoin is still one of the most efficient antiepileptic drugs. If the duration of status epilepticus can be shortened by prompt treatment, neurological complications may be prevented.

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